Abstract: Tuberculosis (TB) is a major cause of childhood death. Despite the startling statistics, it is\nneglected globally as evidenced by treatment and clinical care schemes, mostly extrapolated from\nstudies in adults. The objective of this study was to formulate and evaluate a reconstitutable dry\nsuspension (RDS) containing isoniazid, a first-line anti-tubercular agent used in the treatment and\nprevention of TB infection in both children and adults. The RDS formulation was prepared by direct\ndispersion emulsification of an aqueous-lipid particulate interphase coupled with lyophilization\nand dry milling. The RDS appeared as a cream-white free-flowing powder with a semi-crystalline\nand microparticulate nature. Isoniazid release was characterized with an initial burst up to 5 min\nfollowed by a cumulative release of 67.88%...............
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